Acute effects of liraglutides on gene expression in the hearts of mice with experimental myocardial infarction. Acute effects of liraglutides on gene expression in the hearts of mice with experimental myocardial infarction

Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce the rates of major cardiovascular events, including myocardial infarction in people with type 2 diabetes, and decrease infarct size while preserving ventricular function in preclinical studies. Nevertheless, the precise cellular sites of GLP-1R expression that mediate the cardioprotective actions of GLP-1 in the setting of ischemic cardiac injury are uncertain. Here, cardiac gene expression profiles regulated by liraglutide were examined using RNA-Seq to interrogate mouse atria and both non-infarcted and non-infarcted ventricular tissue after acute coronary artery ligation. Overall design: Bulk RNA-seq was performed on the atria, and non-infarcted and infarcted regions of the left ventricle isolated from mice with experimental myocardial infarction.