Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for Th17 cell differentiation. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA269056
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资源简介：
We analyzed the ChIP-seq data of Brd2 and Brd4 in Th17 cells. We find that Brd2 and Brd4 have distinct genome-wide deposition in Th17 cells, further experiments reveal tht Brd2 faciliates TF-complex formation in enhancers, enhancer-promoter interaction while Brd4 enhances transcriptional elongation. Overall design: ChIP-seq study of Brd2, Cohesin and Brd4 in Th17 cells. Additional samples include Nipbl, Smc1, Smc3 ChIP-seq samples. The Th17 cells are differentiated for 48hrs and ChIP with the corresponding antibodies and ChIP-seq libraries are made. Additional samples are intended to determine the global occupancy of cohesin proteins.
创建时间：
2014-12-02
