ASRGL1 and TDP-43 staining in human brains (ALS patients and controls)

Decreased levels of ASRGL1 in ALS patients associate with TDP-43 proteinopathy. ASRGL1 immunostaining of brain samples. Motor cortex samples (Broadman area 6) of ALS individuals (n=4), multiple sclerosis individuals (MS) (n=4), Alzheimer’s disease (AD) (n=4), and normal controls (NC) (n=4) were immunostained for ASRGL1. Visual cortex samples (Broadman area 17) from the same ALS individuals were also stained for ASRGL1 and consecutive slides of those samples were stained for TDP-43.