Metadata record for the article: Characterisation of PALB2 tumours through whole exome and whole transcriptomic analyses

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related article: “Characterisation of PALB2 tumours through whole exome and whole transcriptomic analyses”. The related study describes molecular characteristics of PALB2 tumours with either germline or somatic alterations. Type of data: whole exome sequencing, RNA sequencing, shallow whole genome sequencing Subject of data: <i>Homo sapiens</i> Sample size: 560 Population characteristics: DNA from fresh frozen tumour tissues and matched peripheral blood lymphocytes of breast cancer patients; RNA from tumour tissues Recruitment: Patients were recruited sequentially from a hospital-based cohort. The hospital in point, Subang Jaya Medical Centre, is a private Malaysian hospital within the Kuala Lumpur metropolitan area, where patients tend to be of higher socio-economic status relative to the general population. <b>Data access</b> Sequencing data for the related study (WES, RNA-seq and sWGS bam files) are available on the <i>European Genome-phenome Archive</i> under the study accession number https://identifiers.org/ega.study:EGAS00001004518. Access to controlled patient data will require the approval of the MyBrCa Tumour Genomics Data Access Committee upon request to the corresponding author at [e-mail]. Characteristics of tumours with germline and somatic PTV identified in PALB2, BRCA1 and BRCA2 carriers are shared openly as part of this data record in the Excel file ‘Datasets 1 2 3.xlsx’. Differentially expressed Genes (DEGs) are shared openly as part of this data record in the file 'Supplementary File 1.xlsx'. <b>Corresponding author(s) for this study</b> Professor Soo Hwang Teo, Cancer Research Malaysia, 1, Jalan SS12/1A, 47500 Subang Jaya, Malaysia. [e-mail]. <br> <b>Study approval </b> Recruitment and genetic studies have been approved by the Ethics Committee of Subang Jaya Medical Centre [reference no: 201208.1] and written informed consent was given by each participant.