Facile Domino Access to Chiral Mono-, Bi-, and Tricyclic 2,3-Dihydrofurans
收藏NIAID Data Ecosystem2026-03-06 收录
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资源简介：
The asymmetric domino Michael-SN2 reaction of various 1,3-dicarbonyl compounds to α-bromonitroalkenes is described for the first time, employing readily available cinchona-derived bifunctional thioureas as organocatalysts. The novel transformations were highly regio-, chemo-, diastereo-, and enantioselective, which simultaneously gave the chiral tricyclic 2,3-dihydrofurans, bicyclic 2,3-dihydrofurans, and tetrasubstituted 2,3-dihydrofurans with two vicinal chiral carbon centers.
创建时间：
2016-02-24
