Text S1 - Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

The Supporting Text S1 file includes: Supporting Figure S1, which details the immunogenetic analysis of HV1-69-sBnAbs; Supporting Figure S2, which details how the CDR-H4 loop was defined; Supporting Figure S3, which describes the design scheme of the semi-synthetic IGHV1-69 Ab library; Supporting Figure S4, which details the isolated anti-H5VN04 and anti-H1CA0409 phage-Ab pools; Supporting Figure S5, which describes the structural role of the HV1-69-sBnAbs distinctive amino acid substitutions in positions 52 and 52a; Table S1, which details studies reporting on the isolation of HV1-69-sBnAbs; Supporting Text, which details the design principles of the semi-synthetic IGHV1-69 Ab library. (DOCX)