The thyroid hormone clearing type 3 deiodinase protects from cardiac congenital abnormalities

We examined the impact of thyroid hormone excess on the mouse fetal heart utilizing a model of deficiency in DIO3, the enzyme that is responsible for clearing thyroid hormones RNA sequencing profile of male fetal hearts at embryonic day E13.5本研究采用DIO3缺陷模型（该酶负责清除甲状腺激素），探究甲状腺激素过量对小鼠胎鼠心脏的影响，并检测了胚胎发育第13.5天（E13.5）雄性胎鼠心脏的RNA测序（RNA sequencing）表达谱。