The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma

For cancer cells to use the haematogenous route of metastasis overcoming anoikis is a prerequisite. By performing RNAseq in melanoma cells, we discovered that after detachment melanoma cells display increased expression of regulators of fatty acid transport and fatty acid beta-oxidation Comparative gene expression profiling analysis of RNA-seq data for adherent and in supension, 501mel and WM266-4 melanoma cell lines, grown with different glucose concentrations.