“Feedback” genes and related proteins (protein ID alphabetical order).

NF-κB controls the transcription of hundreds of genes. Forty-nine of them code for proteins that belong to the UNION interactome, i.e. that participate in the activation of NF-κB. The circuit “interaction with NF-κB pathway → transcription factor activation → transcriptional regulation → interaction with NF-κB pathway” establishes a number of feedback loops that can play a role in the dynamics of the NF-κB system. In bold the four NF-κB components which transcription is regulated by NF-κB itself.