Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Design_and_Synthesis_of_Non_Peptide_Selective_Orexin_Receptor_2_Agonists/2118667
下载链接
链接失效反馈官方服务：
资源简介：
Orexins
are a family of neuropeptides that regulate sleep/wakefulness,
acting on two G-protein-coupled receptors, orexin receptors 1 (OX1R)
and 2 (OX2R). Genetic and pharmacologic evidence suggests that orexin
receptor agonists, especially OX2R agonist, will be useful for mechanistic
therapy of the sleep disorder narcolepsy/cataplexy. We herein report
the discovery of a potent (EC50 on OX2R is 0.023 μM)
and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist,
4′-methoxy-N,N-dimethyl-3′-[N-(3-{[2-(3-methylbenzamido)ethyl]amino}phenyl)sulfamoyl]-(1,1′-biphenyl)-3-carboxamide 26.
创建时间：
2016-02-12
