Additional file 4 of Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

Additional file 4. Full metabolomics results from VITdAL-ICU and RoCI Cohorts. Six Individual Worksheets include Day 0 t test VITdAL-ICU: t test results of Day 0 data from the VITdAL-ICU cohort; Day 0 VITdAL-ICU: Linear regression results of Day 0 data from the VITdAL-ICU cohort adjusted for age, sex, baseline 25(OH)D, SAPS II, and admission diagnosis; Day 0,3,7 VITdAL-ICU: Mixed effects regression results of Day 0,3,7 data from the VITdAL-ICU cohort adjusted for age, sex, baseline 25(OH)D, absolute increase in 25(OH)D at day 3, SAPS II, plasma day, admission diagnosis, and an individual subject-specific random-intercept; Day 0,3,7 VITdAL-ICU Placebo: Mixed effects regression results of Day 0,3,7 data from the VITdAL-ICU cohort in patients who received Placebo adjusted for age, sex, baseline 25(OH)D, absolute increase in 25(OH)D at day 3, SAPS II, plasma day, admission diagnosis, and an individual subject-specific random-intercept; Day 0 t test RoCI: t test results of Day 0 data from the RoCI cohort; Day 0 RoCI: Linear regression results of Day 0 data from the RoCI cohort adjusted for age, sex, race, and APACHE II score. T-statistics are presented for t tests. Beta coefficients are presented for linear regression and mixed effects analysis. In all worksheets, raw p values are presented. A false discovery rate adjusted p value (q value) threshold of 0.05 was used to identify all significant differences.