Metabolome of pig endometrium and placenta.

Neonatal mortality is mostly due to a reduced piglet maturity. An essential question for adaptation to extra-uterine environment lies in the optimization of the crosstalk between maternal and fetal genomes for a distribution of resources that allows fetuses to express healthier phenotypes at birth. The CO-LOcATION project proposes an integrative biology approach combining transcriptomics, metabolomics, lipidomics and maturity phenotypes to answer this crucial question for both research and pig production sustainability. The project will use samples from the former ANR PORCINET project, which produced pure genotypes and reciprocal crossbreed genotypes with contrasted robustness at birth. The complexity of the maturity phenotypes will be addressed by studying the trade-off between growth and survival with a focus on endometrial-placental interactions using whole-genome approaches.