The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and X
Investigating type I interferon in prediabetic stage of DCs from NOD mice compared to C57BL/6.g7 and Rag KO mice. Overall design: RNAseq was used to study splenic cDC1, cDC2, pDC, moDC, and monocyte p
Immune-checkpoints are powerful inhibitory molecules that promote tumor survival. Their blockade is now recognized as providing effective therapeutic benefit against cancer. HLA-G, a recently identifi
Recently, ‘don’t eat me’-signals like CD47 have emerged as novel innate immune checkpoints, enabling cancer cells to evade clearance by phagocytes such as microglia (MG) or monocyte-derived cells (MdC