Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment

Purpose: The aim of the work was to analyze the metabolites of the intestinal microbiota from patients with mild cognitive impairment (MCI) due to Alzheimer's disease and progressive MCI due to Alzheimer's disease.
Method: Two cohorts were established. The first one included 87 subjects with 30 healthy controls (NC), 22 patients with MCI due to Alzheimer's disease, and 35 patients with Alzheimer's disease (AD). The second cohort included 87 patients with MCI due to Alzheimer's disease, who were followed up for 2 years, and finally were divided into progressive MCI due to Alzheimer's disease group (P-G) and unprogressive MCI due to Alzheimer's disease group (U-G) according their cognitive levels. Fecal samples were collected from all patients at the baseline time point. Differential metabolites were subjected to pathway analysis by MetaboAnalyst.
Results: In the first cohort, we found 21 different metabolites among the three groups (AD, MCI, and NC). In the second cohort, we identified 1..., , , # Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment

In this study, we assessed the cognition of 87 community-dwelling elderly individuals aged 65 or older. Based on the degree of cognitive impairment, they were divided into three groups: 35 individuals with Alzheimer's disease (AD), 22 individuals with mild cognitive impairment (MCI), and 30 individuals with normal cognitive function. Demographic data including gender, age, education level, smoking status, and alcohol consumption were collected at baseline. Additionally, fecal samples were collected from all patients for analysis of serum levels of P-tau181, NF-light, Aβ1-42, Aβ1-40 and GFAP. Blood cells were also collected for APOE genotype testing. Furthermore, metabolites in the gut microbiota were analyzed through fecal sample testing. Subsequently, a two-year follow-up was conducted to assess cognitive function in these groups. Participants were categorized as either p...