Microarray analysis of an synthetic a-synuclein induced cellular model

To uncover new disease-associated genes and their relevant mechanisms, we carried out a gene microarray analysis based on a Parkinson’s disease (PD) in vitro model induced by a-synuclein oligomers. The result do help to reveal the mRNA and lncRNA profile in a-syn induced cells and rotenone-stimulated cells. This cellular model of SY-SH5Y cells induced by 25 mmol/L a-synuclein oligomers or 10mmol/L rotenone has been confirmed to show the stable, transmissible neurotoxicity of a-synuclein, a typical PD pathological marker. And the microarray analysis was performed upon two distinct PD cellular model and normal contrl cell.