Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity by activating the DAXX/MEK/ERK1/2 pathway

Heart failure (HF) is the end stage of several cardiovascular diseases and has a high prevalence worldwide. Tanshinone IIA (Tan IIA) is a pharmacologically active lipophilic component of Salvia miltiorrhiza extract that exerts a significant cardioprotective effect in the clinic; however, the specific mechanisms underlying the protective effect of Tan IIA are not fully understood. In this study, Doxorubicin (DOX) was used to mimic HF in vitro model. RNA-sequencing showed that the expression of genes was altered by DOX and Tan IIA.