Additional file 6 of Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

Additional file 6: Supplementary File 4. Alu editing index (AEI) values from the RNA Editing Indexer method (Roth et al., 2019) for (A) the PRJEB38849 MCMV dataset, (B) the ZIKV PRJNA487357 dataset, (C) the ZIKV PRJNA358758 dataset, and (D) the hiNPC ZIKV PRJNA551246 dataset. This includes quantifications of the ratio of A-to-G mismatches to total A reads (effectively the percent of As edited to Gs) in Alu repeat elements in humans or SINE B1/B2 repeat elements in mice, as well as the same metric for other variant types. A-to-G editing index serves as a general metric of transcriptome-wide levels of hyperediting, which primarily occur in repeat regions. Quantification of other variants serve as a measure of background noise, with the next most common modification type being C-to-T editing.