Delineation of hub genes related to ferroptosis and radiosensitivity in breast cancer with three identified subtypes

This study aimed to explore the roles of radiotherapy-sensitive and ferroptosis genes in breast cancer (BRCA). Genes differentially expressed pre- and post-radiotherapy from the GSE59733 dataset were intersected with ferroptosis-related genes. Through a protein-protein interaction network, 10 hub genes were identified. BRCA patients were categorized into three clusters, with cluster 1 and cluster 2 showing the most significant survival difference. Cluster 1 demonstrated higher immune infiltration levels but poorer response to immune therapy compared to cluster 2. Moreover, cluster 1 and cluster 2 exhibited sensitivity to different drugs. These 10 hub genes can effectively classify patients and suggest potential drugs.