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Transcriptome analysis of mesothelial cells induced by intraperitoneal injections of crocidolite in rats

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149285
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Malignant mesothelioma (MM) is an aggressive tumor strongly associated with asbestos exposure. The granuloma capturing crocidolite contribute to mutagenesis, cell death and regenerative activity. To clarify the biological responses of mesothelial cells after crocidolite exposure, we compared the microarray gene expression profiles of no treatment and crocidolite exposure (1 wks) mesothelial cells induced by intraperitoneal injections. Crocidolite exposure protocol was performed using specific pathogen-free male Fischer344 rats. A total of 6 microarrays were used for the expression analysis: The first 3 microarrays were used for no treatment peritoneal mesothelial cells, the next 3 microarrays for crocidolite exposure (1 wks) mesothelial cells.
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2020-09-08
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