Sperm

Methotrexate (MTX ) is commonly used for the treatment of certain cancers including but not limited to leukemia, Hodgkin's disease and head and neck cancers and causes reproductive damage in mice. The aim of this research, is to study the effects of catechin aqueous extract on some parameters of sperms and histopathological changes in testis of mice treated with methotrexate.
The results showed significant (P<0.05) decrease in sperms motility , increased percentage of dead sperms and abnormalities of sperms in mice treated with MTX, there was significant (P<0.05) decrease in diameters of seminiferous tubules, primary spermatocytes and spermatids, increased interstitial spaces as compared with control, while in the second group result showed significant (P<0.05) increase in sperms motility , decreased percentage
of dead and abnormalities of sperms and significant (P<0.05) increase in diameters of seminiferous tubules, primary spermatocytes and spermatids and decrease interstitial spaces compared with first and third groups.

甲氨蝶呤（MTX）作为一种广泛用于治疗包括但不限于白血病、霍奇金淋巴瘤和头颈部癌症等癌症的药物，其在小鼠中会引起生殖系统损伤。本研究旨在探究儿茶素水提物对接受甲氨蝶呤治疗小鼠精子某些参数以及睾丸组织病理学变化的影响。研究结果显示，接受MTX治疗的小鼠精子活力显著降低（P<0.05），死精子和异常精子的比例增加，与对照相比，生精小管的直径、初级精母细胞和精子细胞的直径显著减小（P<0.05），间质空间增加；而在第二组中，结果显示精子活力显著增加（P<0.05），死精子和异常精子的比例降低，与第一组和第三组相比，生精小管的直径、初级精母细胞和精子细胞的直径显著增加，间质空间减小。