Late recurrence-associated long non-coding RNA NR2F1 antisense 1 (NR2F1-AS1) II
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128617
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资源简介：
Long non-coding RNA NR2F1 antisense RNA1 (lncRNA NR2F1-AS1) was identified as the main candidate associated to late recurrence in ER-positive breast cancer clinical samples. Gain-of-function of NR2F1-AS1 induced the expression of dormancy-inducers BMP4 and DEC2, and upregulated pluripotency markers NANOG and OCT4. Representative pathways entailed to metastatic events such as HER2/Neu, hypoxia, EMT and inflammatory-response were also found enriched. We identified the lncRNA NR2F1 antisense RNA1 (NR2F1-AS1) as the main candidate associated to late recurrence in ER-positive breast cancer. We conducted in vitro gain-of-function of NR2F1-AS1 variant1 and variant 4 in breast cancer BT474 cell line and applied microarray-based analysis.
创建时间：
2020-06-21
