BindingDB Entry 2169: Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

Small molecule binding data for protein Fibroblast growth factor receptor 1, Hepatocyte growth factor receptor, Insulin-like growth factor I receptor, JAK3/JAK1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 14, SRC, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase ZAP-70, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O60674, P06239, P08069, P08581, P11362, P12931, P35968, P43404, P52333, P53779, Q02763, Q06187, and Q16539本数据集为针对以下蛋白质的小分子结合数据：成纤维细胞生长因子受体1（Fibroblast growth factor receptor 1）、肝细胞生长因子受体（Hepatocyte growth factor receptor）、胰岛素样生长因子I受体（Insulin-like growth factor I receptor）、JAK3/JAK1、丝裂原活化蛋白激酶10（Mitogen-activated protein kinase 10）、丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14）、SRC、酪氨酸蛋白激酶BTK（Tyrosine-protein kinase BTK）、酪氨酸蛋白激酶JAK2（Tyrosine-protein kinase JAK2）、酪氨酸蛋白激酶ZAP-70（Tyrosine-protein kinase ZAP-70）、血管内皮生长因子受体2（VEGF-receptor 2）；此外还包含同时靶向酪氨酸蛋白激酶SRC与血管内皮生长因子受体2、酪氨酸蛋白激酶TIE-2（KDR与TIE2）的相关结合数据。本数据集对应的通用蛋白质知识库（UniProt）登录号依次为O60674、P06239、P08069、P08581、P11362、P12931、P35968、P43404、P52333、P53779、Q02763、Q06187及Q16539。