Additional file 9 of Exploring the ATN classification system using brain morphology

Additional file 9. Assessment of face validity of the ACH using selected ROIs in the ADNI2 subsample. ROI based comparison of the evidence for a for monotonic volume decline over 24 sequences obtained by permutation of the ACH progression sequence. Braak stage volumes were obtained using aggregated Freesurfer ROI volumes. AP 1: A+T-N-➔A+T+N-➔A-T-N-➔A+T+N+; AP 2: A+T-N-➔A-T-N-➔A+T+N-➔A+T+N+; Other2: A-T-N- ➔ A+T+N- ➔ A+T-N- ➔ A+T+N+; Other4: A-T-N- ➔ A+T+N+ ➔ A+T+N- ➔ A+T-N-. Neurodegeneration (N) by aHV.