Abnormal PrP Properties as Assessed by Western Blot, PK Digestion ELISA and Strain Typing ELISA in 41 French Sporadic CJD Patients and 12 Iatrogenic CJD Patients Originating either from France or the United Kingdom

Sp, Sporadic; DM, iatrogenic cases linked to dura mater grafts; GH, iatrogenic cases linked to growth hormone treatment.
aPatients originating from the United Kingdom.
bExpress the PK concentration for which, when increasing PK concentration, the ELISA PrPSc signal reach an arbitrary cut-off value set at 20% of the signal observed with a PK concentration of 50 µg/ml.
cExpress the ratio of ELISA signal obtained (A/A′) after PrPsc PK digestion differential PK digestions in a non-perturbing detergent mixture (A), and a denaturing (SDS) detergent mixture (A′).