Structure of eIF2B bound to a activator

Structure of eIF2B bound to a activator Descriptor: Isoform 2 of Translation initiation factor eIF2B subunit delta, N,N'-[(1S,2S,4R)-2-hydroxybicyclo[2.2.2]octane-1,4-diyl]bis[2-(4-chloro-3-fluorophenoxy)acetamide], SULFATE ION, ... Authors: Jain, R, Jakob, C.G, Qiu, W. Deposit date: 2026-04-01 Release date: 2026-06-03 Last modified: 2026-06-17 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Discovery of Fosigotifator, a Potent eIF2B Activator with Desired Properties for Human Studies. J.Med.Chem., 69, 2026