Transcriptomic changes in Sin3A deficient CD4 T cells
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE196615
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Highly purified CD4+ T cells from Rosa26-CreERT2 +/- Sin3AF/F micewere then cultured in interleukin 7 (IL-7) in the absence or the presence of 4-hydroxytamoxifen (TAM) for 6 days to allow Cre expression in the absence of cell division or differentiation . Next, we compared the behavior of Sin3A sufficient and deficient T cells in Th17 skewing conditions. RNA was then isolated and sequenced for the analysis of differential expression of mRNA transcripts Sin3A deficient and Sin3A suficient CD4 T cells were cultured for 3 days in Th17 polarizing conditions. mRNA was then purified and analyzed by RNA-sec
创建时间：
2023-03-20
