Dehydrative Allylation of α C(sp3)–H Bonds of Alkylamines with Allylic Alcohols
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https://figshare.com/articles/dataset/Dehydrative_Allylation_of_C_sp_sup_3_sup_H_Bonds_of_Alkylamines_with_Allylic_Alcohols/12350816
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Herein reported is a dehydrative coupling reaction of alkyl amines with allylic alcohols promoted by co-operation of photoredox and palladium catalysts. A range of homoallylic amines are efficiently synthesized. A mechanistic study suggests that an in situ generated carboxylic acid activates an allylic alcohol to facilitate its oxidative addition onto palladium.
创建时间:
2020-05-20



