Biological functions of genes surrounding SNPs from the two-locus interaction. Results from GeneTrail.

A total of 187 genes from the interaction analysis were put into the GeneTrail software.Surrounding genes were defined by either Grail (www.broadinstitute.org/mpg/grail/) or the Genome Browser (http://genome.ucsc.edu/). Gene families located in the same region were manually curated so that only one gene in each family remained in each region, based on a similar official gene symbol.Size of test set: 186 (173 known). Number of known ref. IDs: 44829.KEGG: number of annotated genes in test set: 52. Genes in reference set: 5405.NIA human disease gene sets: number of annotated genes in test set: 20. Genes in reference set: 1487.