Efficient Preparation of a 1,3-Diazidocyclitol as a Versatile 2-Deoxystreptamine Precursor
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/Efficient_Preparation_of_a_1_3_Diazidocyclitol_as_a_Versatile_2_Deoxystreptamine_Precursor/3334486
下载链接
链接失效反馈官方服务：
资源简介：
A synthesis route toward 2-deoxystreptamine, a common structure in many of the clinically
important aminoglycosides, is presented. Starting from p-benzoquinone and cyclopentadiene,
2-deoxystreptamine is synthesized with key steps involving Pd(0)-catalyzed rearrangement, a retro-Diels−Alder by flash vacuum thermolysis, and Yb(III)-directed regioselective epoxide opening. The
obtained diazidocyclitol 17 is a suitable 2-deoxystreptamine precursor, conveniently protected for
incorporation in new aminoglycoside entities.
创建时间：
2016-05-06
