Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue

Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue Descriptor: (1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid, GLYCEROL, POTASSIUM ION, ... Authors: Keown, J.R, Fodor, E, Grimes, J.M. Deposit date: 2019-07-02 Release date: 2019-11-06 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region. J.Med.Chem., 62, 2019H5N1甲型流感病毒聚合酶帽连接区（Cap-Midlink）与帽结构域结合类似物形成复合物的晶体结构 配体描述：(1S,2S,3S,6R)-2-[[2-[5,7-二氟-1H-吲哚-3-基]-5-氟嘧啶-4-基]氨基]-3,6-二甲基环己烷-1-羧酸、甘油、钾离子…… 作者：Keown, J.R、Fodor, E、Grimes, J.M. 提交日期：2019-07-02 发布日期：2019-11-06 最后修改日期：2024-05-15 实验方法：X射线衍射（分辨率1.35 Å） 引用文献：《靶向流感PB2帽结合区域的新型吲哚类化合物的设计、合成及生物学评价》，刊载于《药物化学杂志（J.Med.Chem.）》，2019年，第62卷。