MAC Sevo N2O Data Plos One.xlsx
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Animals were initially anesthetized with SEVO in oxygen (O<sub>2</sub>) and exposed to an electrical current as supramaximal noxious stimulus in order to determine MAC<sub>SEVO</sub> (in duplicates). Thereafter, 70% N<sub>2</sub>O was added to the inspired gas and the MAC re-determined in the presence of N<sub>2</sub>O (MAC<sub>SN</sub>). A subgroup of sheep were anesthetized a second time with SEVO/N<sub>2</sub>O for re-determination of MAC<sub>SN</sub>, after which atipamezole (0.2 mg/kg, IV) was administered for MAC<sub>SNA</sub> determinations. Sheep were anesthetized a third time, initially with only SEVO/O<sub>2</sub> to re-determine MAC<sub>SEVO</sub>, after which atipamezole (0.2 mg/kg, IV) was administered for determination of MAC<sub>SA</sub>.
