The minimum concentration (nM) of ketamine (Ket) and Ket metabolites required to elicit maximum increase in the expression of the monomeric form of SR (m-SR) in PC-12 cells.

The effect of the configuration at the chiral centers at saturating concentration of each compound is represented as the enantioselectivity factor α derived from Concentration(2R isomer)/Concentration(2S isomer). The values for (R)-Ket and (S)-Ket were obtained from [17].