官方服务:
资源简介:
1Also inhibits the Class IIa enzyme HDAC 9.
应用场景:
创建时间:
2015-12-02
相关数据集
Design, Synthesis, and Pharmacological Evaluation of Novel N ‑Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors
This manuscript describes a novel class of N-acylhydrazone (NAH) derivatives that act as histone deacetylase (HDAC) 6/8 dual inhibitors and were designed from the structure of trichostatin A (1). Para
NIAID Data Ecosystem30
Receptor-independent ectopic activity of PROLACTIN predicts aggressive lung tumors and indicates HDACi-based therapeutic strategies
Aim: PROLACTIN (PRL), normally produced by the pituitary gland, acts through its receptor (PRL-R) to initiate a signalling cascade to the genome. PRL can also be produced by cancer cells and become on
NIAID Data Ecosystem20
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influences on MEF2-dependent transcription (RNA-Seq)
In leiomyosarcoma class IIa HDACs bind MEF2 and convert these transcription factors into repressors to sustain proliferation. Theoretically, disruption of this complex should reverse the transformed p
NIAID Data Ecosystem10
Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling
Dissymmetric cross metathesis of alkenes as a convergent and general synthetic strategy allowed for the preparation of a new small series of human histone deacetylases (HDAC) inhibitors. Alkenes beari
NIAID Data Ecosystem20
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia
Using a microwave-assisted protocol, we synthesized 16 peptoid-capped HDAC inhibitors (HDACi) with fluorinated linkers and identified two hit compounds. In biochemical and cellular assays, 10h stood o
Figshare2022-11-09 更新10



