Cytoplasmic lncRNAs accumulate upon CHX-induced translation elongation inhibition

To investigate the role of translation in the decay of cytoplasmic lncRNAs, we performed RNA-Seq in WT and upf1-delta yeast cells, treated or not with CHX.为探究翻译过程在细胞质长链非编码RNA（long non-coding RNA, lncRNA）降解中的作用，我们对野生型（Wild Type, WT）及upf1基因缺失型酵母细胞开展了RNA-Seq实验，实验中分别设置了环己酰亚胺（Cycloheximide, CHX）处理组与未处理组。