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Transcriptome analysis among young and senescent fibroblasts expressing shLuciferase or shFbxo22

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https://www.ncbi.nlm.nih.gov/sra/SRP297908
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We carried out the analysis using human skin fibrobllast HCA2 (MJ90) cells dox-inducible shLuciferase or shFbxo22. Cells were indcued to be senescent cells by treatment with 10 Gy. As a result, Gene set enrichment analysis revealed a significant increase in the expression of lysomal-related and autophagosomal genes in control cells, whereas this gene ontology was not increased in cells depleted of Fbxo22 Overall design: Examination of young and senescent HCA2 cells expressing dox-inducible shLuciferase or shFbxo22.
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2023-12-15
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