Acute modulation of brain connectivity in Parkinson disease after Automatic Mechanical Peripheral Stimulation: a pilot study

Objective: The present study shows the results of a double-blind sham-controlled pilot trial to test whether measurable stimulus-specific functional connectivity changes exist after Automatic Mechanical Peripheral Stimulation (AMPS) in patients with idiopathic Parkinson Disease. Methods: Eleven patients (6 women and 5 men) with idiopathic Parkinson Disease underwent brain fMRI immediately before and after sham or effective AMPS. Resting state Functional Connectivity (RSFC) was assessed using the seed-ROI based analysis. Seed ROIs were positioned on basal ganglia, on primary sensory-motor cortices, on the supplementary motor areas and on the cerebellum. Individual differences for pre- and post-effective AMPS and pre- and post-sham condition were obtained and first entered in respective one-sample t-test analyses, to evaluate the mean effect of condition. Results: Effective AMPS, but not sham stimulation, induced increase of RSFC of the sensory motor cortex, nucleus striatum and cerebellu...研究目的：本研究呈现一项双盲假对照预试验的结果，旨在检验特发性帕金森病（idiopathic Parkinson Disease）患者接受自动机械外周刺激（Automatic Mechanical Peripheral Stimulation, AMPS）后，是否存在可测量的刺激特异性功能连接改变。 研究方法：11名特发性帕金森病患者（6名女性、5名男性）在接受假刺激或有效AMPS前后，即刻接受脑功能磁共振成像扫描。采用基于种子区感兴趣区（seed-ROI）的分析方法评估静息态功能连接（Resting State Functional Connectivity, RSFC），种子ROI分别置于基底神经节、初级感觉运动皮层、补充运动区以及小脑。分别提取有效AMPS干预前后与假刺激前后的个体差异数据，先开展单样本t检验分析，以评估该干预条件的平均效应。 研究结果：有效AMPS而非假刺激，可诱导感觉运动皮层、纹状体与小脑的RSFC增强……