Synthesis of Highly Enantioenriched All-Carbon Quaternary Centers: Conjugate Additions of Chiral Organolithium Nucleophiles to α,α-Dinitrile β,β-Disubstituted Olefins
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资源简介：
Highly enantioenriched quaternary centers are obtained by the reaction of chiral lithiated intermediates complexed to (−)-sparteine with tetrasubstituted, α,α-dinitrile activated olefins. Lithiated N-Boc-N-Aryl benzylamine furnishes products with drs from 78:22 to 95:5, with ers exceeding 94:6. Lithiated N-Boc-N-Aryl allylamine reactants provide enecarbamate products with drs from 55:45 to 99:1, with ers ranging from 87:13 to 97:3.
创建时间：
2016-08-20
