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One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann–Ohira Reagent

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Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/One_Pot_Two_Step_Conversion_of_Aldehydes_to_Phosphonyl_and_Sulfonylpyrazoles_Using_Bestmann_Ohira_Reagent/2495518
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A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann–Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.
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2016-02-20
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