A dataset of histopathological whole slide images for classification of Treatment effectiveness to ovarian cancer (Ovarian Bevacizumab Response)

The dataset consists of de-identified 288 hematoxylin and eosin (H&E) stained whole slides with clinical information of HGSOC patients from 288 patients. The slides were collected from the tissue bank of the Tri-Service General Hospital and the National Defense Medical Center, Taipei, Taiwan. WSIs were acquired with a digital slide scanner (Leica AT2) with a 20x objective lens. The dimension of the ovarian cancer slides is 54342x41048 in pixels and 27.34 x 20.66mm on average. The Bevacizumab treatment is effective in 162 and invalid in 126 of the dataset. Ethical approvals have been obtained from the research ethics committee of the Tri-Service General Hospital (TSGHIRB No.1-107-05-171 and No.B202005070), and the data were de-identified and used for a retrospective study without impacting patient care.

The clinicopathologic characteristics of patients were recorded by the data managers of the Gynecologic Oncology Center. Age, pre- and post-treatment serum CA-125 concentrations, histologic subtype, and recurrence, and survival status were recorded. A tumor, which is resistant to bevacizumab therapy, is defined as a measurable regrowth of the tumor or as a serum CA-125 concentration more than twice the value of the upper limit of normal during the treatment course for the bevacizumab therapy (i.e., the patient had the detectable disease or elevated CA-125 level following cytoreductive surgery combine with carboplatin/paclitaxel plus bevacizumab). A tumor, which is sensitive to bevacizumab therapy, is defined as no measurable regrowth of the tumor or as a serum CA-125 concentration under than twice the value of the upper limit of normal during the treatment course for the bevacizumab therapy.