We aim to better understand the molecular mechanisms of infectious disease and identify potential therapeutic and diagnostic targets by exploiting next-generation genomic data. A major focus is the co
CAB2 mutant derived from the clinical isolate RimD2210633. CAB2 lacks TDH hemolysins and its T3SS1 is not functional by means of deletion of exsA, a gene encoding the T3SS1 transcription regulator.
Virulence-relevant KOs Database allows the prediction of bacterial virulence factor genes from 16S-based metagenomics using Phylogenetic Investigation of Communities by Reconstruction of Unobserved St
Global properties of the three constituent networks and the integrated network. The sequence similarity network excludes nodes with no edges (‘orphan’ proteins with no sequence similarity matches). Co
Fungal plant pathogen mutagenomics reveals tagged and untagged mutations in Zymoseptoria tritici and identifies SSK2 as key morphogenesis and stress-responsive virulence factor
