Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom

Protein Data Bank Japan2024-03-13 更新2026-03-21 收录

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Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID Authors: Van Zandt, M.C, Jones, M.L, Gunn, D.E, Geraci, L.S, Jones, J.H, Sawicki, D.R, Sredy, J, Jacot, J.L, Dicioccio, A.T, Petrova, T, Mitschler, A, Podjarny, A.D. Deposit date: 2005-03-14 Release date: 2006-03-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.04 Å) Cite: Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications J.Med.Chem., 48, 2005

分辨率1.04埃的与烟酰胺腺嘌呤二核苷酸磷酸（NADP+）及抑制剂利多司他（lidorestat）结合的人醛糖还原酶复合物晶体结构 Descriptor: 二氢烟酰胺腺嘌呤二核苷酸磷酸（NADPH）、醛糖还原酶（aldose reductase）、{3-[(4,5,7-三氟-1,3-苯并噻唑-2-基)甲基]-1H-吲哚-1-基}乙酸 Authors: Van Zandt, M.C.、Jones, M.L.、Gunn, D.E.、Geraci, L.S.、Jones, J.H.、Sawicki, D.R.、Sredy, J.、Jacot, J.L.、Dicioccio, A.T.、Petrova, T.、Mitschler, A.、Podjarny, A.D. Deposit date: 2005-03-14 Release date: 2006-03-14 Last modified: 2024-03-13 Method: X射线衍射（X-RAY DIFFRACTION，分辨率1.04埃） Cite: 《3-[(4,5,7-三氟苯并噻唑-2-基)甲基]吲哚-N-乙酸（利多司他）及其同系物：作为治疗慢性糖尿病并发症的强效高选择性醛糖还原酶抑制剂的发现》，《药物化学杂志》（J.Med.Chem.），48卷，2005年

创建时间：

2005-03-14