Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z54750053 (A71EV2A-x0359)

Protein Data Bank Japan2024-10-16 更新2026-04-19 收录

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Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z54750053 (A71EV2A-x0359) Descriptor: 4-[(dimethylamino)methyl]benzonitrile, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16型（Coxsackievirus A16）G-10株2A蛋白酶晶体片段筛选数据集集体提交——结合配体Z54750053（A71EV2A-x0359）的柯萨奇病毒A16型G-10株2A蛋白酶晶体结构配体描述：4-[(二甲氨基)甲基]苯甲腈、二甲基亚砜、2A蛋白酶等作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Balcomb, B.H.、Capkin, E.、Chandran, A.V.、Golding, M.、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X.、Thompson, W.、Tomlinson, C.W.E.、Wild, C.、Winokan, M.、Xavier, M.-A.E.、Fearon, D.、von Delft, F. 提交日期：2024-04-04 发布日期：2024-04-24 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率1.07埃）引用文献：《柯萨奇病毒A16型2A蛋白酶晶体片段筛选发现广谱抗肠病毒开发新机遇》，BioRxiv预印本平台，2024年

创建时间：

2024-04-04