Summary of EC<sub>50</sub>s from experiments measuring IP<sub>1</sub> accumulation and ERK<sub>1/2</sub> phosphorylation.
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HEK293 cells were transiently transfected with the WT CaSR or disease-associated CaSR mutants. Cells were then treated with various levels of [Ca2+]o. The EC50s of [Ca2+]o-IP1 responses and the -[Ca2+]o-ERK1/2 phosphorylation activity responses were obtained from curve fitting using the Hill equation as mentioned in Method. # indicates significance with respect to wild type CaSR, p<0.05 (ANOVA, Dunnett test); * indicates significance with respect to the corresponding mutants in the absence of L-Phe, p<0.05 (two-way ANOVA). Summary of EC50s from experiments measuring IP1 accumulation and ERK1/2 phosphorylation.
创建时间：
2014-11-24
