Blocking promiscuous activation at cryptic promoters directs cell typeâspecific gene expression
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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This SuperSeries is composed of the SubSeries listed below.AbstractTo selectively express cell typeâspecific transcripts during development, it is critical to maintain genes required for other lineages in a silent state. Here, we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific zinc finger protein, Kumgang (Kmg), working with the chromatin remodeler dMi-2 prevents transcription of genes normally expressed only in somatic lineages. By blocking transcription from normally cryptic promoters, Kmg restricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male germ cell differentiation. Our results suggest that as new regions of the genome become open for transcription during terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activation.
创建时间：
2022-02-20
