The G protein-coupled type 1 cannabinoid receptor (CB1R) mediates virtually all classic cannabinoid effects, and both its agonists and antagonists hold major therapeutic potential. Heterologous expres
Adhesion G Protein-coupled receptors (aGPCRs) transduce extracellular adhesion events into cytoplasmic signaling pathways. ADGRG6/GPR126 is an aGPCR critical for axon myelination, heart development an
MCHR1-Gi complex,S2 state Descriptor: Antibody fragment ScFv16, Fusion protein 1,Melanin-concentrating hormone receptor 1,Fusion protein 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit ga
Activity of several ion channels is controlled by heterotrimeric GTP-binding proteins (G proteins) via a membrane-delimited pathway that does not involve cytoplasmic intermediates. The best studied ex