rmMFG-E8 promotes neural stem cell migration via netrin-1.

(A) rmMFG-E8 upregulates netrin-1 via integrin αV. Pre-treatment of mouse embryonic neural stem cells with 1 mg/ml anti-Itgav antibody prevented rmMFG-E8 mediated upregulation of netrin-1, but not 1 mg/ml control IgG. Data are presented as mean ± SEM. *p+BrdU+) at 7 days after tMCAO. Representative images are shown at the top of the figure. tMCAO increased the number of Doublecortin+BrdU+ cells in the striatum compared to sham baseline. rhMFG-E8 treatment significantly increased the number of Doublecortin+BrdU+ cells compared with the vehicle group. Data are presented as mean ± SEM. *p