Data for: EFFECTIVENESS OF THE NICOTINE PATCH IN THE CONTROL OF PAIN, EDEMA, AND TRISM IN THIRD MOLAR SURGERY: A RANDOMIZED CLINICAL TRIAL.

Objective: to evaluate nicotine patch effectiveness in the control of pain, edema and trismus in lower third molar surgery. Materials and Methods: A prospective, randomized, triple blind split-mouth trial was performed wiih 20 patients who underwent two surgical procedures at different times. In the control intervention, a nicotine patch without the active principle was used (placebo), whereas a patch containing 14 mg nicotine was used in the experimental group. Results: It was observed that the nicotine patch was effective in pain control at 4 and 8 hour intervals with values of p = 0.023 and p = 0.005, respectively. The adhesive patch containing the active principle also showed significant statistical results for edema control in the first 24 hours (p = 0.004), 48 hours (p = 0.005), 72 hours (p = 0.007) and 7 days (p = 0.046) following the intervention. Postoperative mouth opening was significantly higher at 72-hour and 7-day intervals in patients who received the nicotine patch. The amount of rescue analgesics was lower when the patch was used (p = 0.026) and the level of satisfaction was statistically relevant for interventions which included the active principle (p = 0.008). Conclusion: The nicotine patch was effective in controlling pain, edema and trismus.研究目的：评估尼古丁贴片（nicotine patch）在下颌第三磨牙手术术后疼痛、水肿与张口受限（trismus）控制中的有效性。 材料与方法：本研究采用前瞻性、随机、三盲分口试验（split-mouth trial）设计，纳入20名于不同时段接受两次下颌第三磨牙手术的患者。对照组使用不含活性成分的尼古丁贴片安慰剂，实验组则使用含14mg尼古丁的贴片。 结果：研究观察到，尼古丁贴片在术后4小时（p=0.023）与8小时（p=0.005）的疼痛控制中效果显著。含活性成分的贴片在术后首个24小时（p=0.004）、48小时（p=0.005）、72小时（p=0.007）及7天（p=0.046）的水肿控制中同样具备显著统计学意义。接受尼古丁贴片治疗的患者，其术后72小时与7天的张口度显著更高。使用贴片的患者急救镇痛药物用量更低（p=0.026），且接受含活性成分干预措施的患者满意度评分具有显著统计学意义（p=0.008）。 结论：尼古丁贴片可有效控制下颌第三磨牙术后的疼痛、水肿及张口受限。