Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD17-26
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD17-26 Descriptor: 1,2-ETHANEDIOL, 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ... Authors: Xu, X, Blacklow, S.C. Deposit date: 2018-02-08 Release date: 2019-01-16 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
人类BRD4首个溴结构域（bromodomain）与抑制剂XMD17-26复合物的晶体结构
描述符：1,2-乙二醇、11-环戊基-2-[[2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]羰基苯基]氨基]-5-甲基-嘧啶并[4,5-b][1,4]苯并二氮杂䓬-6-酮、含溴结构域蛋白4（Bromodomain-containing protein 4）……
作者：Xu, X、Blacklow, S.C.
提交日期：2018-02-08
发布日期：2019-01-16
最后修改日期：2023-10-04
检测方法：X射线衍射（1.58埃）
引用文献：《调控嘧啶并苯并二氮杂䓬酮类作为激酶与溴结构域抑制剂选择性的结构与阻转异构因素》，ACS Chem. Biol., 13, 2018
创建时间：
2018-02-08
