Transphosphorylation of pLIMK1

Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.

Hsp90与LIMK蛋白的结合作用可保护其免受降解，并促进其二聚体形成及跨磷酸化。据估计，LIMK1在其激酶结构域中至少含有5个磷酸化氨基酸，主要为磷酸化丝氨酸。这些丝氨酸残基的具体位置尚不明确。对LIMK1中这些丝氨酸残基的跨磷酸化作用可增强其稳定性。