Aging Skin and Comorbidities in Atopic dermatitis – Are Advanced Glycation End Products Guilty? : Dataset

Advanced glycation end products (AGEs) interact with the membrane-bound receptor for AGEs (RAGE), consequently amplifying the inflammatory response. Soluble receptor for AGE (sRAGE) and endogenous secretory RAGE (esRAGE) act as decoys for AGE and competitively sequester RAGE ligands, thereby serving a cytoprotective role. Our objective was to investigate AGE expression and their receptors in the serum and skin of patients with atopic dermatitis (AD). In this case-control study, the levels of AGE, sRAGE, and esRAGE were measured in the blood samples and corneocytes of 29 adult patients with AD and 12 healthy controls by ELISA. Corneocyte AGE levels increased in the AD group (P = .002). Higher corneocyte AGE levels were observed in the severe AD than in the mild AD. No significant difference in serum AGE level was observed in patients with AD and healthy controls. Serum sRAGE markedly decreased in patients with AD (P = .007) and serum esRAGE followed a similar trend. In conclusion, dermal accumulation of AGE in AD may have a role in skin inflammation and aging. The potential after-effects of reduced neutralizer on systemic risk need further evaluation.晚期糖基化终末产物（Advanced glycation end products, AGEs）可与AGEs膜结合受体（receptor for AGEs, RAGE）结合，进而放大炎症应答。可溶性AGE受体（soluble receptor for AGE, sRAGE）与内源性分泌型RAGE（endogenous secretory RAGE, esRAGE）可作为AGEs的诱饵受体，竞争性结合RAGE配体，从而发挥细胞保护作用。本研究旨在探究特应性皮炎（atopic dermatitis, AD）患者血清与皮肤组织中AGEs及其受体的表达情况。本项病例对照研究采用酶联免疫吸附试验（enzyme-linked immunosorbent assay, ELISA），检测了29例成人特应性皮炎患者与12例健康对照者的血液样本及角化细胞中的AGEs、sRAGE与esRAGE水平。特应性皮炎组患者的角化细胞AGEs水平显著升高（P=0.002）。重度特应性皮炎患者的角化细胞AGEs水平高于轻度特应性皮炎患者。特应性皮炎患者与健康对照者的血清AGEs水平无显著差异。特应性皮炎患者的血清sRAGE水平显著降低（P=0.007），血清esRAGE水平亦呈现类似变化趋势。综上，特应性皮炎患者皮肤中AGEs的蓄积可能与皮肤炎症及衰老相关。中和因子水平降低对全身系统风险的潜在后续影响仍需进一步评估。